The Medical Evidence

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Sublingual Immunotherapy Works: The Medical Evidence

Long-lasting Effects of Sublingual Immunotherapy According to its Duration: A 15-year Prospective Study

Journal logoJournal of Allergy and Clinical Immunology, November 2010

Maurizio Marogna, MD*; lgino Spadolini, MD**; Alessandro Massolo, BS***; Giorgio Walter Canonica, MD****; Giovanni Passalacqua, MD****

*Pneumology Unit, Cuasso al Monte, Macchi Hospital Foundation, Varese, ltaly

**Medical Department, Anallergo, Florence

***The Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary

****Allergy and Respiratory Diseases, Department of lnternal Medicine, Genoa, University, Genoa, ltaly

This study followed patients for 15 years. The researchers showed that patients treated for four years with allergy drops had more than eight years protection after stopping their last set of drops. The patients’ symptoms abated and remained in remission. No pharmacological agent for allergy has ever shown this much of a long-term benefit without any side-effects.

 

Preventive Effects of Sublingual Immunotherapy in Childhood: An Open Randomized Controlled Study

Annals logoAnnals of Allergy, Asthma & Immunology, Volume 101, August 2008

Maurizio Marogna, MD.; Dante Tomassetti, MD*; Antonella Bernasconi, MD*; Fausto Colombo, MD*; Alessandro Masselo, BS**; Andrea Di Rienzo Businco, MD***; Giorgio W. Canonica, MD****i Giovanni Passalacqua, MD****; and Salvatore Tripodi, MD***

*Pneumology Unit, Cuasso al Monte, Macchi Hospital Foundation, Varese, ltaly

**Department of Animal Biology, University of Pavia, Pavia, ltaly

***Pediatric Allergy Unit, S. Pertini Hospital, Rome, ltaly

****Allergy and Respiratory Diseases, Department of lnternal Medicine, Genoa, University, Genoa, ltaly

This study, which has been supported by other studies, found that the patients who are treated with allergy drops reduced the onset of new allergen sensitization and were less likely to develop persistent asthma. This is especially important to parents and to pediatricians because it addresses why intervening with allergy drops in children can be a life-changing therapy.

 

Sublingual Immunotherapy with a Standardized Cat Dander Extract: Evaluation of Efficacy in a Double-Blind Placebo Controlled Study

Placebo vs Active and symptom score

Placebo vs Active, and symptom score

Allergy, 2007

E. Alvarez-Cuesta*; P. Berges-Gimeno*; E.G. Mancebo”; E. Fernandez-Caldas”*; J. Cuesta-Herranz***; M. Casanovas**

*Servicio de Alergia Hospital Ramon y Cajal; **Laboratorios LETI, S.L., Tres Cantos

***Servicio de Alergia, Fundacion Jimenez Diaz, Madrid, Spain

This study demonstrates that cat allergies can be successfully treated with allergy drops. Cat and animal allergy is a big problem in many practices, and many patients fear exposure to a cat or dog which can trigger allergic and asthmatic symptoms.

 

Letters to the Editor: Quantitative Assessment of the Compliance with a Once-Daily Sublingual Immunotherapy Regimen in Real Life

Journal of Allergy and Clinical lmmunology, April 2006

(EASY Project: Evaluation of A novel SLIT Formulation During a Year)

Chart showing patient compliance using allergy drops

Chart showing greater patient compliance using allergy drops

G. Walter Canonica, MD, Department of Internal Medicine, University of Genoa (ltaly)

This letter to the editor reviews data showing that patients on allergy drops had over 75 percent compliance in completing the full course of treatment, and of the 75 percent that completed the program, over 90 percent of doses were taken – high results for a home-based program. In comparison, allergy injections typically only have 30 to 40 percent patient compliance. The reasons are quite clear: injections are uncomfortable and inconvenient, and these factors influence compliance, especially in a treatment that is year-round.

 

Efficacy and Safety of Sublingual lmmunotherapy

Annals of Allergy, Asthma & Immunology, Volume 93, July 2004

Giovanni Passalacqua, MD*; Laura Guerra, MD*; Mercedes Pasquali, MD”; Carlo Lombardi, MD**; and Giorgio Walter Canonica. MD*

*Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, ltaly

**Allergy service, Department of Internal Medicine, s. Orsola Hospital, Brescia, ltaly

This article reviews many studies of allergy drops, clearly demonstrating the safety of using this therapy in adults and children, which is a major concern because of the adverse reactions that have been experienced with allergy injections over the years, including anaphylaxis and even death. The authors show that only mild reactions have occurred with sublingual, making its wide safety margin an attractive feature of this therapy. They also cite the numerous studies that show the efficacy of sublingual immunotherapy in helping to reduce symptoms and medications as well as the development of new allergies.

 

Non-injection Routes for Immunotherapy

Journal of Allergy and Clinical Immunology, March 2003

how allergy drops decrease symtoms

How allergy drops decrease symtoms and need for medication

G. Walter Canonica, MD, and Giovanni Passalacqua, MD, Department of Internal Medicine, University of Genoa (ltaly)

Dr. Walter Canonica is one of the leading allergy experts in the world and a past president of the World Allergy Organization. He has done much of the initial research that has brought sublingual allergy immunotherapy to mainstream academic and clinical allergists. In this article, he uses data from his own seminal work showing that sublingual allergy immunotherapy can decrease a patient’s symptoms and need for medication while on the sublingual allergy treatment (drops) and even seven years later after therapy was stopped.

Allergy Drops in Action: Sima’s Story: The Gift of Breath

the story of Sima, and how she ran a triathalon

The story of Sima, and how she ran a triathalon

Completing the Nautica NYC Triathlon on Sunday, July 26, 2009, was one of the most exciting accomplishments of my life.

When I started training, I could not run a mile outdoors without wheezing and needing to take a break due to shortness of breath. I was using two different inhalers, hoping that they would open my airways just enough to get me through training.

I had been a seasonal allergy sufferer for as long as I can remember. As I grew up, my allergies worsened and the amount of time I suffered increased. I started with springtime allergies and soon began to suffer into the summer months. And by my early twenties, I had symptoms in the fall as well. My symptoms ranged from itchy, teary eyes to pneumonia-like shortness of breath. I took eye drops, pills, and nasal sprays for eight or nine months out of the year. Needless to say, I loved the winter!

In high school, it was recommended that I try allergy shots. I went weekly for my shots for about two years. Each week, my arm would become severely inflamed.

My doctor told me that he could not increase the dose I was receiving because of how severe my reaction was each week. With no sign of improvement, I chose to stop the shots. Each spring, I braced myself for the suffering, spent too much time indoors with the air conditioner on, and medicated round the clock.

I finally began seeing Dr. Dean Mitchell for allergy drops in May 2008. I began training to run my first triathlon in February of the next year. While I did wheeze through the first few weeks of training, Dr. Mitchell supported me through it with medical advice, suggesting when to take the inhalers to increase their yield and minimize my reliance on them.

Sima training for the Triathalon

Sima training for the Triathalon

Spring 2009, a little less than a year into my drop therapy, my training was in full flux, and I was doing it outdoors. It was the first spring that I can remember that I was spending time outside, was not taking medication morning and night, and did not feel the intense urge to scratch my face off. Finally allergy free, my lungs and I were able to complete a triathlon.

More important than all the coaching, Dr. Mitchell gave me the gift of breath. With that breath I now run three times a week in New York’s beautiful Central Park year round. I prefer working out outdoors than in the gym… and I don’t carry tissues with me.

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